RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
SMAD4
RNA ID
RNA Type
mRNA
Alteration Pattern
promoter hypermethylation
Species
homo sapiens
Detection Methods
qRT-PCR; PCR-SSCP etc.
Target
NA
Pathway
NA
PubMed ID
Title
Reduced transcription of the Smad4 gene during pulmonary carcinogenesis in idiopathicpulmonary fibrosis
Year
2009
Function
Expression levels of Smad4 were significantly lower in tumors from lung cancer/IPF patients than in those from lung cancer patients without IPF or in lung cancer cell lines. The loss of the growth inhibitory response to TGF-B signaling may be crucial in pulmonary carcinogensis or in the progression of lung cancer in IPF patients in whom TGF-B is overexpressed; Hypermethylation of the Smad4 promoter region may be one mechanism by which this occurs.